SCREEN – emerging technologies in 3D ex vivo imaging
In drug discovery processes, there has been a growing shift from laboratory-based 2D in vitro approaches towards 3D ex vivo-based platforms.
3D ex vivo platforms are also being developed into better drug efficacy testing systems in preclinical profiling of novel anticancer entities. Within this context, there is a growing need for improving ways to image and analyze complex 3D structures like multicellular tumor spheroids and organoids.
Our partner SCREEN has developed both fluorescence and novel OCT-based technologies which have eliminated the need for fluorescent staining.
Applications include:
- spheroid/organoid imaging
- growth and morphological profiling of 3D spheroids
- quantification of internal cavities
- drug sensitivity testings
- large tissue imaging
- non-invasive monitoring of macro and sprouted neo vasculature
