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Quartz Cristal Microbalance with Dissipation (QCM-D)

BioNavis QCMD instruments offer precise and reliable solutions tailored to your research needs, supporting various applications and ensuring accurate results

QCMD technology is a powerful analytical tool used to measure minute changes in mass, viscoelastic properties, or morphology of films on a sensor´s surface. By leveraging the piezoelectric properties of quartz crystal sensors, QCMD instruments provide highly sensitive measurements. Selecting the right sensor type is crucial for achieving optimal results in your specific application

Further information

QCMD Measurement Principle

The measurement principle of the Quartz Crystal Microbalance (QCM) technology involves harnessing the inherent properties of a quartz crystal resonator. When an alternating electric voltage is applied to the crystal, it undergoes mechanical oscillations at a specific frequency. As molecules or thin films are deposited onto the surface of the sensor, they cause changes in mass, density, and viscoelastic properties. These alterations modify the resonant frequency and dissipation of the crystal. The resonant frequency shifts in proportion to the added mass, allowing for precise measurement of mass changes. Meanwhile, changes in dissipation reflect alterations in the energy dissipated during the crystal’s oscillation, providing insights into the viscoelastic properties of the deposited material.

By monitoring both the frequency shift and dissipation changes over time, researchers can obtain comprehensive information about the adsorbed layers, including their mass, thickness, rigidity, and solvent content. This capability makes QCMD a powerful tool for studying processes such as thin film formation, biomolecular interactions, surface chemistry, and material characterization. In research and industrial applications, QCMD technology plays a crucial role in fields ranging from biotechnology and pharmaceuticals to materials science and nanotechnology.

Models

QCMD 100

Modular QCMD 100

Separate modules allowing you to choose desired features
Easy expansion and addition of modules as research requirements grow
Fits diverse budgetary need

The Quartz Crystal Microbalance with Dissipation – QCMD 100 instrument for electrochemistry measures both frequency and dissipation, facilitating precise measurements of molecule-surface interactions.

Suited for applications:

Electrochemistry

bionavis.com/product/qcmd-100/

QCMD 110

Enhanced single channel QCMD 110

Integrated temperature control (15 - 65°C) for flow cell and sample inlet
Exceptional maximum time resolution of 500 measurement points per second

Enhanced single-channel Quartz Crystal Microbalance with Dissipation, QCMD 110, offers exceptional sensitivity in both frequency and dissipation, facilitating precise measurements of molecule-surface interactions.

Suited for applications:

Biosensors
Biomaterials
Biophysics

bionavis.com/product/qcmd-110/

QCMD 400

Four flow cell QCMD 400

Four flow cells enabling measurement on separate sensors simultaneously for higher throughput
Individual temperature control for each cell
Precise syringe pumps enabling individual flow characteristics for each cell

The multichannel Quartz Crystal Microbalance with Dissipation, QCMD 400, offers time-saving operations and superior sensitivity in both frequency and dissipation. It enables the measurement of molecule-surface interactions across a wide range of applications.

Suited for applications:

Biosensors
Biomaterials
Biophysics
Layers and Coatings

bionavis.com/product/qcmd-400/

Precise syringe pump

Integrated control of the liquid flow for high quality data
Versatile - allow push and pull configuration and wide flow-rate range for sample injection
Used in QCMD 400 and 110 models (optional for 100)

Optional: Advanced flow control unit with integrated degasser, sample injector valve and capability of handling multiple carrier fluids.

QCMD Quartz Crystals

The essence of the QCMD technology lies in oscillating quartz crystal sensor with electrodes on both sides. High-quality of sensors are essential for successful measurements. QCMD sensors enable you to achieve precise and reliable measurements.

Classical QCMD sensors 5MHz.
Designed to work up to the 13th overtone.
Functionalize your sensor in situ or ex situ. Easy ex situ coatings with spin coating, self-assembly or other techniques of your preference.
Sensor coatings include :
Silicon dioxide (SiO2) coated sensors for coatings, antifouling, and easy deposition of lipid bilayers.
Gold (Au) sensor slides provide a versatile platform and are typically used for biosensor development, and thin film characterization.
Available also Platinum (Pt), Cupper (Cu) and Aluminium (Al).
Ask for custom made surfaces.

Specifications

BioNavis QCMD instruments measure fundamental frequency and 6 overtones as well as dissipation for comprehensive data. All instrument models contains:

Very easy sensor placement with QuickLock cells
Transparent lid allowing user to view the sensor surface during the measurement
Precise syringe pumps for improved liquid control
All instrument models can be equipped with:
High frequency (HFF-QCM) sensors for unparallel sensitivity with dedicated flow cell
Electrochemical cell