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Spatially Resolved DLS

NanoFlowSizer from InProcess-LSP

The NanoFlowSizer is a particle size analyzer with the unique Spatially Resolved Dynamic Light Scattering (SR-DLS) technology. It is fully developed to satisfy the Process analytical technology (PAT) requirements for several applications related to nanoparticles formulations and characterizations.

The SR-DLS overcome the limitation of a conventional DLS being able to measure turbid suspension without dilute it directly in the production phase. This entails a series of significant advantages such as: the possibility to perform analysis during the flow both In-Line than On-Line, allows fast measurements, no samples preparations or wasting etc…

Features

Match PAT requirements
InLine, OnLine, At-Line, Off-Line and static analysis
Modular configurations
Analysis on highly turbid highly concentrated samples without dilution
Real time process monitoring
No sample preparations
Non-destructive analysis
Single & Multiple scattering diagnosed automatically
Flow measurements Up to 300L/hr

Further information

The quality cannot be verified in the products; it should be incorporated into the design.

On this statement it was designed the Process analytical technology (PAT) protocol by the United States Food and Drug Administration (FDA).

The idea is to define a framework with the aim of improving any production process especially in the pharmaceutical industry, where the measurement of critical process parameters (CPP) is of fundamental importance to ensure the quality of the final product.

The PAT framework helps to understand the CPPs and, accordingly, to monitor them in a timely manner by IN-LINE and ON-LINE measurements, such framework allowing you to be more efficient in testing, reducing over-processing, enhancing consistency and efficiency as well as minimizing rejects and therefore increasing production.

Conventional DLS uses laser light to obtain a single scatter pattern from the interaction with the particles in the samples, in the SR-DLS technology multiple wavelengths light sources are used and, instead of one, about 1000 scatter patterns are obtained simultaneously as function of depth of any single particle in the sample.

The obtained backscattered signals are collected and analysed by an interferometer which enables to distinguish between scatter signals coming from different path length. This is the Low Coherence Interferometry (LCI) principle.

Once the scatter patterns are obtained as function of depth, each of these are processed and translated into particle size accordingly to the Stokes-Einstein equations

Adding the depth of the particles, as an extra-dimension, in the particle sizing framework, defines the stark difference between conventional DLS and SR-DLS.